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Resume of YTO, Ph.D.
Consultant

EXPERTISE AND SERVICES

Molecular and Cellular Biology Expert, Biotechnology and Pharmaceutical Consultant, Analytical Biochemistry Specialist, Clinical Researcher, Metabolic Biochemistry Consultant, Forensic Investigation and Analysis, Expert Consulting Services
Expertise in biochemistry, molecular and cellular biology, analytical biochemistry, clinical research design and execution, metabolic biochemistry, vitamin and dietary supplement research, antioxidants, nutraceuticals, and botanicals.

Additional areas of related expertise include CFR 21 and California Prop. 65 regulatory compliance, analytical validation, cGMP training and SOP review, quality assurance/quality control, system documentation and auditing, NDI and GRAS documentation for FDA and USDA.

This consultant's work experience includes technical writing, HPLC, electrochemistry, microscopy, database solutions, clinical study IRB, grant writing, integrated system design, laboratory data acquisition systems, lab safety training, MSDS, laboratory design and layout.

This KKAI consultant is highly regarded in areas including high performance liquid chromatography, gas chromatography, thin layer chromatography, microscopy (phase, fluorescence, confocal, SEM), solid and liquid phase extraction, electrophoresis (protein, nucleic acids) biochemistry, human anatomy and physiology, mammalian physiology, microbiology, ecology & evolution, plant ecology, plant morphology, genetics

PRINCIPAL INDUSTRIES SERVED
Biotechnology, Botanical, Dietary Supplement, Clinical Research, Molecular and Cellular Biology, Pharmaceutical

EDUCATION
Ph.D., Molecular and Cellular Biology, Oregon State University, Corvallis, OR
B.S., Biology, Southern Oregon University, Ashland, OR

PROFESSIONAL EXPERIENCE
Consultant, Kevin Kennedy & Associates, Inc.

Providing expertise in molecular and cellular biology, biotechnology and pharmaceuticals, analytical biochemistry, clinical research, metabolic biochemistry, and related expertise to a wide variety of clients.

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Case Studies

President and owner, Scientific Consulting firm

Designed and executed clinical studies, analyzed and presented data & results. Developed QA and compliance systems for dietary supplement and botanical industry clients. Wrote and submitted scientific manuscripts for publication. Developed technical documents including NDI & GRAS documentation. Provided GMP, safety and technical training to clients.

Analytical Chemist, erb Pharm, Inc., Williams OR

Designed QA systems and SOPs for chemical analysis of pharmaceutical grade herbal extracts. Performed analytical R&D experiments, worked with QA/QC, production, marketing and farm departments. Repaired, calibrated and maintained all lab instruments and computers. Trained technicians and interns. Taught physiology and phytochemistry classes.

Research Associate, Linus Pauling Institute, Oregon St. Univ. Corvallis, OR

Investigated the role of chronic inflammation in age-associated cardiovascular dysfunction. Self generated salary and research funds with grants from the NIH-Center for Complimentary and Alternative Medicine and OSU Center for Healthy Aging. Analyzed the clinical potential for antioxidant and chelation therapies. Maintained calibrated and repaired analytical laboratory instruments and computers.

Instructor, Oregon St. Univ. Dept. of Biochemistry & Biophysics, Corvallis, OR

Taught Biochemistry, including lectures, writing and administering midterm and final exams, managing two teaching assistants, maintaining course webpage and office hours. Led recitations and review sessions.

Research Assistant, Oregon St. Univ. Corvallis, OR

Investigated the biochemical and physiological changes that occur in cardiovascular aging and the response to antioxidant therapies. Self funded salary and research materials with grant from the American Heart Association. Trained and supervised undergraduate research assistants, taught courses, managed data collection and analysis. Published six original research manuscripts and collaborated on several others.

ADDITIONAL EXPERIENCE

Research grant: Oregon State University Center for Healthy Aging. Funding for research equipment and reagents
Invited speaker: Linus Pauling Institute Annual Retreat
Invited speaker: Biochemical Society Symposium on Stress, Signaling and Control. University of Essex, Colchester, UK
Invited speaker: NATO- Advanced Science Institute: 59th Course. Nitric Oxide: Basic research and clinical applications. Erice, Sicily, Italy
Pre-doctoral fellowship: American Heart Association. Funding for student stipend, travel and research materials for two years
Post-doctoral fellowship: National Institutes of Health. Funding for doctoral stipend, travel and research materials for two years

HONORS AND AWARDS
Biochemical society & Pfizer young researcher award: Biochemical Society Symposium. University of Essex, Colchester, U

PROFESSIONAL AFFILIATIONS
American Herbal Products Association: Analytical Laboratory Committee
Biochemical Society
American Heart Association
American Heart Association Council for High Blood Pressure Research
Sigma Xi Scientific Research Honor Society

PUBLICATIONS
Numerous publications on topics including Lipoic acid significantly restores the age-related decline in vasomotion, The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects, Age-related Changes in Endothelial Nitric Oxide Synthase Phosphorylation and Nitric Oxide Dependent Vasodilation: Evidence for a Novel Mechanism Involving Sphingomyelinase and Ceramide-Activated Phosphatase 2A, Plasma Membrane-Associated Endothelial Nitric Oxide Synthase and Activity in Aging Rat Aortic Vascular Endothelia Markedly Decline with Age, Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart, Age associated increases in oxidative stress and antioxidant enzyme activities in the cardiac intrafibrillar mitochondria: implications for the mitochondrial theory of aging, Lipoic Acid as a Potential therapy for Chronic Diseases Associated with Oxidative Stress, Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration, Vitamin C matters. Increased oxidative stress in cultured human aortic endothelial cells without supplemental ascorbic acid, Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independent of cellular GSH status, Vitamin C and lipoic acid lower oxidant production in cultured HAEC: Implications for age-related endothelial dysfunction, and more.

Please note that this is an abbreviated CV. A fully detailed unabridged CV is available under special circumstances.

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Kevin Kennedy & Associates, Inc.
Rapid Response Engineering® Solutions
3905 Vincennes Road, Suite 320
Indianapolis, Indiana 46268
(317) 536-7000 voice
(317) 536-7220 fax

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